Infantile fibrosarcoma with TPM3-NTRK1 fusion in a boy with Bloom syndrome
نویسندگان
چکیده
منابع مشابه
Infantile Fibrosarcoma in a Child: a Case Report
Abstract Background Infantile Fibrosarcoma is a rare soft tissue tumor in infants and children mostly located in extremities. An infantile and adult form has similar histopathological patterns but survival prognosis is much better in infantile form. Recurrence of infantile fibrosarcoma is common but the rates of metastasis are less than 10 percent in children younger than five Years and 50 p...
متن کاملEvaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib.
We present a case of a reverse transcription polymerase chain reaction (RT-PCR) ETV6-NTRK3 negative congenital infantile fibrosarcoma (CIFS) harboring an LMNA-NTRK1 gene fusion with an eight-month ongoing, near-complete response to crizotinib. CIFS is a rare, typically low-grade sarcoma of children younger than age two years and is associated with a good to excellent prognosis, with an 80% medi...
متن کاملCongenital infantile fibrosarcoma: Association with bleeding diathesis
PATIENT Male, 2 month FINAL DIAGNOSIS Congenital infantile fibrosarcoma Symptoms: Bleeding Medication: Vincristine • actinomycin • cyclophosphamide Clinical Procedure: Surgical resection Specialty: Pediatric Oncology. OBJECTIVE Diagnostic/therapeutic accidents. BACKGROUND Congenital infantile fibrosarcoma (CIF) is a soft-tissue tumor occurring during the first 2 years of life, most common...
متن کاملInfantile Fibrosarcoma With NTRK3–ETV6 Fusion Successfully Treated With the Tropomyosin‐Related Kinase Inhibitor LOXO‐101
Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractory IFS with constitutive activation of the tropomyosin-related kinase (TRK) signaling pathway from...
متن کاملHypercalcemia of Malignancy in a Newborn with Infantile Fibrosarcoma.
Figure 2. Subcutaneous calcinosis (black arrow) developed on the ankle, at a prior intravenous catheter site. Figure 1. Panel A. MRI showing 9.2 by 7.5 by 8.9 cm heterogeneous mass with vessels scattered throughout. Panel B. Biopsy of the mass showing spindle and plump cells, along with a vascular pattern similar to that of a hermangiopericytoma. Hypercalcemia of Malignancy in a Newborn with In...
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ژورنال
عنوان ژورنال: Familial Cancer
سال: 2020
ISSN: 1389-9600,1573-7292
DOI: 10.1007/s10689-020-00221-1